Tiantian Cai, Kui Han, Peilin Yang, Zhou Zhu, Mengcheng Jiang, Yanyi Huang*, and Can Xie*, Reconstruction of Dynamic and Reversible Color Change in Cephalopods using Reflectin Protein. 2019  (Scientific Reports, Accepted).


Kelong Fan, Bing Jiang, Zhe Guan, Jiuyang He, Dongling Yang, Ni Xie, Guohui Nie, Can Xie*, and Xiyun Yan*. Fenobody: A Ferritin-Displayed Nanobody with High Apparent Affinity and Half-Life Extension. Anal Chem. 90 (9), 5671–5677 (2018).

Zhe Guan, Tiantian Cai, Zhongmin Liu, Yunfeng Dou, Xuesong Hu, Peng Zhang, Xin Sun, Hongwei Li, Yao Kuang, Qiran Zhai, Hao Ruan,  Xuanxuan Li, Zeyang Li, Qihui Zhu, Jingeng Mai, Qining Wang, Luhua Lai, Jianguo Ji, Haiguang Liu, Bin Xia, Taijiao Jiang, Shu-Jin Luo, Hong-Wei Wang, Can Xie*, Origin of the reflectin gene and hierarchical assembly of its protein. Current Biology, 27, 833–2842, 2017 doi:10.1016/j.cub.2017.07.061 

(It was selected as Cover Story of Current Biology, and was highlighted by ‘Nature Research Highlights’)



Siying Qin, Hang Yin, Celi Yang, Yunfeng Dou, Zhongmin Liu, Peng Zhang, He Yu, Yulong Huang, Jing Feng, Junfeng Hao, Jia Hao, Lizong Deng, Xiyun Yan, Xiaoli Dong, Zhongxian Zhao, Taijiao Jiang, Hong-WeiWang, Shu-Jin Luo and Can Xie*, A magnetic protein biocompass, Nature Materials, 15(2): 217-226. 2016 (advance online publication, 16 November 2015 (DOI 10.1038/nature4484)).


Fangwei Leng, Can Xie*, and Da-Cheng Wang*. Structure and Self-assembly of NLRP10. Progress in Biochemistry and Biophysics, 2015, 42(12): 1112-1118.


Christopher S. Kollmann, Xiaopeng Bai, Ching-Hsuan Tsai, Hongfang Yang, Kenneth E. Lind, Steven R. Skinner, Zhengrong Zhu, David I. Israel, John W. Cuozzo, Barry A. Morgan, Koichi Yuki, Can Xie, Timothy A. Springer, Motomu Shimaoka, Ghotas Evindar , Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists , Bioorganic & Medicinal Chemistry , 2014

Liu L, Jin L, Huang X, Geng Y, Li F, Qin Q, Wang R, Ji S, Zhao S, Xie Q, Wei C, Xie C, Ding B, Li Y. , OsRFPH2-10, a RING-H2 Finger E3 Ubiquitin Ligase, Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection , Mol Plant , 2014 



Xie C, Zhu J, Chen X, Mi L, Nishida N, Springer TA , Structure of an integrin with an aI domain, complement receptor type 4. , EMBO J , 2010 , 29(3): 666-679., (It is the first complement receptor structure and also the first αI domain integrin structure.)  

Xing Chen, Can Xie, Noritaka Nishida, Zongli Li, Thomas Walz, and Timothy A. Springer , Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2 , Proc. Natl. Acad. Sci. USA , 2010 , 107: 14727-32


Xie C, et. al, , Stabilized Low Affinity Conformation of Integrins for Drug Discovery. , US Patent , 2008 , NP Ref: 033393-063940-P; ,(The patent is about a new technology of expressing and purifying huge, heterodimeric, glycoprotein with mammalian expression systems)

Vorup-Jensen, T, Chi, L, Gjelstrup, LC, Jensen, UB, Jewett CA, Xie, C, Shimaoka M, Linhardt RJ, Springer TA, Binding between the integrin αXβ2 (CD11c/CD18) and heparin. J. Biol. Chem.  2007, 282:30869-77.


Cao W, Liu J, Chen T, Cao Y, He X, Mu R, Zhou H, Xie C, Chen S, Zhang J. Ethylene receptor signaling and plant salt-stress responses. Advances in Plant Ethylene Research, 2007, 333-339.


Nishida N*, Xie C*, Shimaoka M, Cheng Y, Walz T, Springer TA, Activation of leukocyte β2 integrins by conversion from bent to extended conformation. Immunity, 2006,  583-594. (* : co-first author) (It is the first EM structure of aI Integrins. It also provided structural basis of integrin activation.)


Xie C, Shimaoka M, Xiao T, Schwab P, Klickstein LB, Springer TA. The integrin α subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proc. Natl. Acad. Sci. USA 2004 101: 15422-15427.


Chen JF, Takagi J, Xie C, Xiao T, Luo BH, Springer TA. The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin α4β7. J. Biol. Chem. 2004, 279: 55556-55561.


Xie C, Zhang JS, Zhou HL, Li J, Zhang ZG, Wang DW, Chen SY, Serine/threonine kinase activity in the putative histidine kinase-like ethylene receptor NTHK1 from tobacco. Plant J. 2003 Jan;33(2):385-393. (It is the first report of Ser/Thr kinase activity, but not Histidine kinase activity of plant ethylene receptor, which overturned a previously proposed mechanism for ethylene signaling based on histidine kinase activity of the receptors.)


Xie C, Zhang ZG, Zhang JS, He XJ, Cao WH, He SJ, Chen SY, Spatial expression and characterization of a putative ethylene receptor protein NTHK1 in tobacco. Plant Cell Physiol. 2002 Jul;43(7):810-815.


Zhang JS *, Xie C *, Shen YG, Chen SY, A two-component gene (NTHK1) encoding a putative ethylene receptor homolog is both developmently- and stress-regulated in tobacco. Thero. Appl. Genet., 2001, 102 (6/7): 815-824 (* : co-first author)


Zhang JS, Xie C, Wu XL, Du BX, Chen SY, Tobacco two-component gene NTHK2, Chinese Science Bulletin, 2001, 46(7): 574-577.


Xie C, Zhang JS, Chen SY, Protein Phosphorylation and two-component system. Progress in Biotechnology. 2001, 21(6), 9-14. (in Chinese)


Wang WM, Zhu LH, Xie R, Xie C, Jin L, Morphological and anatomical analysis of a floral organ mutant in rice, Acta Botanica Sinica, 2000, 42(4): 379-382.


Xie C, Zhang JS, Chen SY, Tobacco floral homeotic gene NFBP6 is specifically expressed during pollen and ovule development, Science in China (Series C), 1999, 42(5),481-484.


Zhang JS, Xie C, Li ZY, Chen SY, Expression of the plasma membrane H+-ATPase gene in response to salt stress in a rice salt-tolerance mutant and its original variety, Theor Appl Genet (1999), 99, (6), 1006-1011.


Zhang JS, Xie C, Liu F, Liu FH, Chen SY, A novel tobacco gene coding for a product similar to bacterial two-component regulators, Chinese Science Bulletin, 1999, 44(11), 1025-1029.


Lin L, Tian X, Hong S, Dai P, You Q, Wang R, Feng L, Xie C, Tian ZQ, Chen X. , A bioorthogonal Raman reporter strategy for SERS detection of glycans on live cells , Angew Chem Int Ed Engl. , 2013 , 2013 Jul 8;52(28):7266-71  


Xu X, Dong GX, Hu XS, Miao L, Zhang XL, Zhang DL, Yang HD, Zhang TY, Zou ZT, Zhang TT, Zhuang Y, Bhak J, Cho YS, Dai WT, Jiang TJ, Xie C, Li RQ, Luo SJ . , The genetic basis of white tigers , Current Biology , 2013 , 1031-1035  


Lianshun Feng, Senlian Hong, Jie Rong, Qiancheng You, Peng Dai, Rongbing Huang, Yanhong Tan, Weiyao Hong, Can Xie, Jing Zhao, and Xing Chen , Bifunctional Unnatural Sialic Acids for Dual Metabolic Labeling of Cell-Surface Sialylated Glycans , J. Am. Chem. Soc. , 2013 , DOI: 10.1021/ja402326z.



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Hefei Institutes of Physical Science

Chinese Academy of Sciences 

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